The homeotherm is one biological organism group which has physiological functions to maintain constant deep body temperature within some discrete range such as 37.0± 0.5 , so-called warm blood animal. As far as the homeotherm lives, the same constant deep body temperature has to be maintained. When the environmental temperature around the homeotherm affects on this maintenance of deep body temperature, basal metabolic rate of these warm blood animals changes in markedly good correspondence with surrounding outer environmental temperature, being coupled with energy production and consumption through respiration and ATP production. When environmental temperature becomes higher than deep body temperature, some heat stresses and/or moderate thermal stress responses occur. Under these thermal conditions, some effective biological and physiological devices are necessary to keep the body safe and take preventive action toward homeostasis disturbing turbulent agents. To meet this biological requirement, heat shock proteins (HSPs) can act as effective supporters for good health maintenance in main. Stresses are classified into two categories such as (1)moderate mild stresses and (2) acute severe stresses. Depending on the extent of thermal stresses, appearance and physiological function of heat shock proteins are different.

As shown in Table 1, various HSP molecules have been reported. Their many physiological functions are completely distinctive and separable each other. Among these various HSP molecules. HSP 70 family is the most important for maintenance of normal healthy active daily life of human beings, although various many HSP molecules are concerned on the whole body levels.

 

Table 1. Family and function of Heat Shock Protein (HSP ) of mammals

Family Localization Characteristics HSP 150 (ORP 150) Endoplasmic reticulum induced by hypoxia HSP 90 family     HSP 100(GPI 95) Endoplasmic reticulum molecular chaperon HSP 90 Cytoplasm steroid receptors HSP70 family     BiP (GRP 78) Endoplasmic reticulum molecular chaperon mtHSP70(75,000) Mitochondria HSP70 of mitochondria HSC 70(73,000) Cytoplasm ordinary molecular chaperon HSP 70(72,000) Cytoplasm stress induced molecular chaperon HSP60 family     HSP60/HSP10 Mitochondria chaperonin in mitochondria TriC Cytoplasm chaperonin in cytoplasm HSP 47 Endoplasmic reticulum chollagen specific chaperon HSP 40 (HdJ 1) Cytoplasm co-work with HSP 70 HSP 27 (smaI HSP) Cytoplasm and Nucleus thermotolerance Hemeoxigenase Endoplasmic reticulum heme compounds break down Ubiqucin Cytoplasm protein break down